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Kidney issues: Particularly in those with pre-existing conditions

Smokers or corticosteroid users may require higher doses to overcome suppression of GH release

This is usually an indication that you have a methylation defect and need to slow down on the amount of B12 you are taking

Also see the levels of plasticizers found in one of the canned tunas we've tested and the popular "greens" supplement AG1

These include: Large disc extrusions or sequestered fragments requiring surgical intervention Severe spinal stenosis with significant canal narrowing Bone spurs (osteophytes) compressing nerve structures Advanced degenerative disc disease with complete disc height loss Spondylolisthesis (vertebral slippage) beyond grade 1 Cauda equina syndrome (medical emergency requiring immediate surgery) Users with these conditions typically report minimal improvement from peptide therapy alone